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Article continues belowArticle continues belowArticle continues below<script type="application/json" data-placement="fcplayer-semantic">{"type":"fcplayer-semantic","data":{"embedCode":"//cdn.fcp.codes/embed-code-template/embed-code-template.js#SEMANTIC_5704afb8-c10b-4ba5-9cb4-d7fb6098ef90"}}</script><ul><li>Dortmund win 2-0, 3-1 on aggregate</li><li>PSV exit UCL in devastating loss</li><li>USMNT trio all feature</li></ul>

Gutting for USMNT trio Malik Tillman, Sergino Dest and Ricardo Pepi! PSV exit UEFA Champions League via devastating loss to Borussia Dortmund

Following a 1-1 first-leg draw in the Netherlands, the two sides had it all to play for on Wednesday in Germany. The hosts, though, struck first, and they struck early to set a tone.The opening goal came just three minutes in, with on-loan winger Jadon Sancho giving his side the advantage. Teed up by Julian Brandt, Sancho was able to pick out a corner with a shot from the edge of the box, giving Dortmund an early advantage while settling nerves both in the team and in the crowd.Dortmund seemingly doubled their lead in the 77th minute on a goal from Niklas Fullkrug, but a tight offside call saw the finish called back, giving PSV some hope. Unfortunately for them, that hope never turned into a goal, while Dortmund got their own late with Marco Reus putting away a stoppage-time finish to seal a 3-1 aggregate win.

WHAT HAPPENED?

With the loss, PSV's focus will now be solely on domestic competitions, having failed to make it out of the Champions League's Round of 16. This season, though, was the first time PSV had made it to the Champions League knockouts since the 2015-16 campaign, when they fell to Atletico Madrid in the same stage.It was a valiant effort from the Dutch side, and they impressed beyond expectations.

THE BIGGER PICTURE

As expected, two of the three USMNT stars were in the XI for PSV just an hour or so after all three were confirmed to be in the <a href="https://www.goal.com/en-us/lists/usmnt-gio-reyna-tyler-adams-nations-league/blt797d338335d91664" target="_blank">U.S. squad for the upcoming CONCACAF Nations League</a>. Dest and Tillman were named to PSV's starting XI, while Pepi was named to the bench before coming on late as a second-half sub.Dest started on the left-hand side at fullback, playing behind Tillman, who took up a spot on the left wing. Of the two, Dest was the more dangerous, as he had one good look at goal and one chance created. Tillman, meanwhile, never quite got going in the attack.Pepi entered the fray in the 82nd minute with PSV pushing hard for a goal, but it never came as the American got just a few touches of the ball.

USMNT IMPACT

Sergino Dest (7/10):Had a few good moments on the left-hand side. Defended fairly well and got forward as he usually does.Malik Tillman (6/10):Couldn't quite get anything going in the attack. Passed the ball fairly well and tracked back when needed, but didn't really impact the game.Ricardo Pepi (N/A):Thrown in during the final minutes, but couldn't save the day.

GOAL'S RATINGS

PSV will return to Eredivisie play this weekend as they play host to FC Twente in their final match before the international break. The matchup is one that features two of the league's three best teams, with PSV 16 points clear of their third-place opponents.

WHAT COMES NEXT?

Gutting for USMNT trio Malik Tillman, Sergino Dest and Ricardo Pepi! PSV exit UEFA Champions League via devastating loss to Borussia Dortmund | Goal.com Cameroon

PSV&apos;s Champions League run is over as the Dutch club&apos;s U.S. men&apos;s national team stars couldn&apos;t save them against Borussia Dortmund.