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Champions League holders Chelsea welcome the most successful team in the history of the competition to Stamford Bridge on Wednesday evening, as Real Madrid visit west London in the first leg of their quarter-final tie.
Thomas Tuchel's side head into the clash following a shock 4-1 derby defeat at home to Brentford at the weekend, while Carlo Ancelotti's men are 12 points clear at the top of La Liga following a hard-fought 2-1 win at Celta Vigo.
Domestic matters, however, will be put to one side by both teams on Wednesday as they focus on their shared goal of claiming more continental success.
Chelsea vs Real Madrid latest odds
The Blues are favourites with bet365 to claim a first-leg victory, priced at 11/10 (2.10) and Chelsea recorded a 2-0 home win against Real Madrid when they met in the semi-finals of last season's competitions.
Los Blancos, meanwhile, can be backed at 13/5 (3.60) while the draw is on offer at 12/5 (3.40).
Chelsea vs Real Madrid first goalscorer
Romelu Lukaku is the shortest-priced player to break the deadlock on Wednesday evening with the Belgium international available at 9/2 (5.50).
For Real Madrid, Karim Benzema is offered at 5/1 (6.00) and the Frenchman is enjoying his best ever scoring season for the Spanish side having already netted 34 goals in all competitions, including eight in the Champions League.
Elsewhere in the market, Kai Havertz and Mason Mount are both priced at 11/2 (6.50) while Vinicius Junior is available at 8/1 (9.00).
Chelsea vs Real Madrid preview
The Premier League side were clearly superior to their Spanish opponents in last season's semi-final although the tie was still in the balance until the Blues scored a second goal in the second leg, five minutes before the end of the game.
This season Real Madrid are generally in better shape, although there is a feeling that Carlo Ancelotti's men are running out of steam heading into the business end of the season.
Los Blancos found their midfield overrun last year by the energy of N'Golo Kante, Jorginho and Mason Mount and there is every chance that Ancelotti decides to play a fourth man in the middle of the park to try and find some equilibrium.
Keeping things tight and staying in the tie for the second leg will be the main concern of the visitors and as such backing another low-scoring game between these sides makes sense.
Chelsea vs Real Madrid tips & predictions
Under 2.5 goals is priced at 8/11 (1.73) and paid out in both legs of their semi-final last season, while opposing both teams to score at 10/11 (1.91) could also be of interest.
Odds correct at the time of writing. 18+. begambleaware.org
Best Bet
Under 2.5 goals at 8/11 (1.73) for a 2pt stake with bet365bet365